To enable the downstream analysis of regulatory targets of TFs, we only focused on the four among the above eight TFs, including HNF4A, RAD21, MECP2 and HSF1 (Fig. 2A,B), which had the available and high quality ChIP-Seq datasets derived from the colorectal cancer cells in the Cistrome Data Browser12. Here, HSF1 is linked to colorectal cancer.