FOXP3 and neoplasm: CD3+ T cells were detected in both the peritumoral tissue and between the tumor cells with a CD3 median IHC score of 4 in both groups (Fig. 2a,e; hematoxylin-eosin staining Fig. 2d), whereas FOXP3 expression, a characteristic of Treg cells, was found in 20.5% of peritumoral samples analyzed (Fig. 2b) and in 13.6% of tumor samples (Fig. 2f).