STK11 and bacterial infectious disease: The Cd11cCreLkb1f/f mice showed a significantly higher survival rate than the Lkb1f/f mice upon lethal E. coli challenge, and reducing the Treg cell population in the Cd11cCreLkb1f/fFoxp3DTR mice through DT treatment resulted in poor survival (Fig. 7f), indicating that conditional knockout of the Lkb1 gene in DCs increases the Treg cell number and the tolerance of the host to primary bacterial infections.