POFUT2 and adenocarcinoma: The most significant DMP in our study appeared to be situated in the body of POFUT2. O-Fucosyltransferase 2 encoded by POFUT2 is proved to restrict epithelial-mesenchymal transition and affect cell motility in mouse embryos [32], and is considered as a useful prognostic biomarker in patients with glioblastoma and adenocarcinoma [33, 34].