Pathway expressions were also visualized in the form of a joyplot (Fig. 2c) and dotplot (Fig. 2d); the results showed hepatitis B, hepatitis C, cAMP, drug metabolism cytochrome P450, measles, JAK/STAT, and PI3K/Akt, and tyrosine metabolism signaling pathways were significantly activated while protein processing in endoplasmic reticulum, lysosome, and rheumatoid arthritis, epithelial cell signaling in helicobacter pylori infection, and phagosome signaling pathways were conspicuously suppressed. Here, AKT1 is linked to rheumatoid arthritis.