CD28 and uveitis: Moreover, they demonstrated that the incubation of peripheral blood mononuclear cells (PBMC) with 1,25(OH)2D3 resulted in reduced proliferation of PBMC and reduced production of IFN-ƴ and IL-17A in the presence of anti-CD3 and anti-CD28 [23], suggesting that vitamin D supplementation might be an adjunctive treatment option for patients with this form of uveitis.