WES revealed that HMCLs displayed frequent mutations in Fanconi anemia genes (PALB2 [12%], FANCI [12%], FANCA [9%], FANCD2 [9%], BRCA2 [9%]) as well as in helicases (such as RECQL4, 15%, and BLM, 15%) and epigenetic modifiers (e.g., TET2, 15% and SETD2, 6%). This evidence concerns the gene RECQL4 and Fanconi anemia.