HMCLs shared a similar mutations rate with MM patients, either at diagnosis (DMM) or relapse (RMM) for DIS3 (12% in HMCLs, 10% in DMM and 13% in RMM), PRDM1 (3%, 2%, and 5%, respectively), BIRC3 (3%, 2%, and 3%, respectively), and EGR1 (3%, 4%, and 4%, respectively) (Fig. 2). This evidence concerns the gene EGR1 and Miyoshi myopathy.