TP53 and plasma cell myeloma: The high TP53 abnormality frequency (67%) in HMCLs identified by WES in our study (and confirmed by direct RT-PCR sequencing [1]) was not in good agreement with a previous WES study reporting a rate of 21% in HMCLs [40], which was highly underestimated: indeed, well-known TP53 mutations in L-363, LP-1, and SKMM-2 (COSMIC database and p53.iarc.fr, Release = 18) were not reported in this study and at least three “HMCLs” were not of myeloma origin (ARH77, MC-CAR, CTV-1) [41, 42].