While mutation rate in KRAS was similar between HMCLs and primary myeloma cells, the frequencies of TP53 (67%), CDKN2C (33%), PRKD2 (21%), FAM46C (15%), and BRAF (15%) dramatically increased compared to primary myeloma cells, either in DMM or RMM. This evidence concerns the gene PRKD2 and plasma cell myeloma.