Considering that ARHGAP11A positively interacted with Rac1B protein, but had no impact on Rac1B mRNA expression, we speculated that ARHGAP11A might affect protein modification of Rac1B in HCC, such as ubiquitination, which was a common form of posttranscriptional modification. This evidence concerns the gene ARHGAP11A and hepatocellular carcinoma.