To determine a putative impact of a deregulation of transcript diversity in disease, we correlated the pathway’s enrichment in APP co-splicing with a recent transcriptional signature of tissue vulnerability to AD [17] The signature is based on expression differences between Braak regions I to III and unaffected brain regions, and it is enriched for pathways that co-aggregate with amyloid-β and tau protein, in plaques and tangles [17]. This evidence concerns the gene APP and Alzheimer disease.