UBQLN1 and early-onset autosomal dominant Alzheimer disease: Since the polymorphism UBQ-8i (rs12344615) in UBQLN1 has been associated with increased risk of late-onset Alzheimer’s disease (LOAD) and differences in UBQLN1 exon 8 splicing, we asked whether APP/UBQLN1 co-splicing was modulated by UBQ-8i.