APP and Alzheimer disease: UBQLN1 links proteosomes and ubiquitin ligases for protein degradation and its variants have been associated to AD [24], APLP2 has been involved in glutamatergic transmission and synaptogenesis in association with APP [25, 26], ATP2A2 is a SERCA Ca(2+) ATPase, involved in calcium homeostasis in the endoplasmatic reticulum, and regulates amyloid-β production [27], ATP6AP2 is a constituent of the renin-angiotensin system whose down-regulation has been associated to AD [28] and DNER promotes glia differentiation activating gamma secretase signaling [29].