Indeed, a large number of tumor-associated macrophages (TAM) in the tumor interstitium induces the production of inflammatory and pro-angiogenetic factors, such as epidermal growth factor (EGF); vascular interleukin-8 (IL-8) and VEGF-A, also matrix metalloproteinases (MMPs), cathepsins, serine proteases, leading to tumor metastatization [7]. The gene discussed is CTSS; the disease is neoplasm.