The apoptosis induced by ATR II in prostate cancer was also found to be mediated through mitochondrial intrinsic pathways, mainly through mediating an overexpression of tumor suppressor p53 that drive an unbalance on the complex Bcl-2/BAX consequently promote the release of cytochrome c, and therefore by cascades activation of caspase9/3. This evidence concerns the gene BCL2 and prostate cancer.