Zhang et al. (2017) [33] carried out a study with C57BL animals where chlorogenic acid (1 mM) was co-administered with DSS, and it was possible to observe a reduction in clinical signs of IBD, such as weight loss, colony weight/length ratio, histological improvement, and suppression of interferon-γ, TNFα and interleukin-6 (IL-6), colonic infiltration of F4/80+ macrophages, CD3+ T cells, and CD177+ neutrophils via the inhibition of the NF-κβ active signaling pathway. Here, TNF is linked to inflammatory bowel disease.