Administration of the extract or of SSZ caused a marked reduction in macroscopic colonic damage, with a decrease in inflammation along the colonic tissue being evidenced in the histological study, along with reduced leukocyte infiltration, preservation of the intestinal architecture, and up-regulation in MUC-2 expression, which is defective in IBD, and which may lead to the deficient stimulation of defensins and favor an imbalance of the intestinal microbiota [29]. This evidence concerns the gene MUC2 and inflammatory bowel disease.