CR downregulation was previously shown to significantly reduce the cell growth and viability of MM cells, particularly in cell lines derived from epithelioid and mixed MM with high CR levels, such as MSTO-211H cells, while the effect of its downregulation is weaker and delayed in cells with endogenously lower levels of CR, such as in SPC111 cells [20]. This evidence concerns the gene CALB2 and Miyoshi myopathy.