NEAT1 was identified as an essential component of the FOXN3–SIN3A repressor complex, and the overexpression of NEAT1 promoted EMT in ERα+ MCF-7 breast cancer cells and promoted the lung metastasis of MCF-7 when orthotopically implanted in the mammary fat pad, suggesting that NEAT1 has oncogenic activity [292]. Here, ESR1 is linked to breast carcinoma.