IRS1 and neoplasm: In multivariate analyses, using Cox regression adjusted to tumor grade, disease stage and expression of hormonal receptors, the rare allele in rs1801160 in DPYD was associated with a significant hazard ratio (HR = 2.58, 95% CI = 1.48–4.50, p = 0.001), but the other two variants (rs17376848 also in DPYD and rs2288587 in IRS1) were non-significant (p = 0.071 and p = 0.115, respectively).