However, anti-CTLA-4 resulted in a similar benefit in men and women when the analysis was restricted to the 4 studies on melanoma (HR 0.67, 95% CI 0.50–0.90, p = 0.008 and HR 0.80, 95% CI 0.68–0.94, p = 0.006, respectively) (Figure 4A,B). This evidence concerns the gene CTLA4 and melanoma.