Moreover, alterations of the lamin A maturation process also give rise to premature aging features as attested by the restrictive dermopathy (RD) and the mandibuloacral dysplasia with type B lipodystrophy (MADB), which arise from mutations in the ZMPSTE24 gene. Here, ZMPSTE24 is linked to mandibuloacral dysplasia with type B lipodystrophy.