After treatment with trichostatin A (TSA), a reversible pan inhibitor of HDAC, the expression levels of CD40L, IL-10 and IFN-gamma were corrected in patient T cells, suggesting the involvement of HDACs in abnormal T cell activation in SLE patients through at least regulating CD40L and IL-10 expression, which are both critically involved in T cell: B cell interaction and B cell activation. This evidence concerns the gene IL10 and systemic lupus erythematosus.