TNF and systemic lupus erythematosus: Type I and type II interferons (TFN I/II), tumor necrosis factors (TNF), B-lymphocyte stimulators (BLys), interleukin 6, interleukin 17, interleukin 18, interleukin 21, and many other cytokines are involved in autoimmune priming and induce inflammatory mediated tissue injury in patients with lupus [19,20,21].