MAPT and early-onset autosomal dominant Alzheimer disease: It seems that ischemic episodes favor the development of Alzheimer’s disease-like neurodegeneration through numerous mechanisms including neuronal loss, synaptic dysfunction, neuroinflammation, accumulation of various parts of the amyloid protein precursor, tau protein dysfunction and dysregulation of Alzheimer’s disease-related genes, white matter lesions, and general brain atrophy.