MAPT and hyperhomocysteinemia: Based on the data presented, it appears that curcumin has its own effective therapeutic potential through anti-amyloid, anti-tau protein hyperphosphorylation, anti-hyperhomocysteinemia, anti-oxidant, anti-inflammatory, and anti-apoptotic effects (Table 1) [116,117,119,143], which clearly indicates that curcumin can be used as a neuroprotective substance not only in ischemic neurodegeneration [33,148] but also in a neurodegenerative disease similar to Alzheimer’s disease as a response to brain ischemia associated with hyperhomocysteinemia [149,150].