MAPT and brain ischemia: Brain ischemia favors the increase of blood–brain barrier permeability, which facilitates the penetration of inflammatory cells into the brain parenchyma and releases a large number of serine proteases, as well as β-amyloid peptides and tau protein from the blood into the brain tissue, which in turn leads to white matter lesions [18,32,57,58,59,60,61,62,63,64,65,66].