MAPT and early-onset autosomal dominant Alzheimer disease: Studies in recent years suggest that ischemic brain damage may promote neurodegeneration of the Alzheimer’s disease-type by damaging neuronal energy, generating reactive oxygen species [27,29], neuroinflammation [29,30,31,32], various parts of amyloid protein precursor accumulation [18,29,33], and tau protein dysfunction [34,35], which in turn damage neuronal cells, especially in the hippocampus and contribute to brain atrophy [33,36,37,38,39].