MSRA and early-onset autosomal dominant Alzheimer disease: Methionine oxidation in Met-35 of amyloid ß-peptide (Aβ peptide) is thought to be critical for aggregation and neurotoxicity [130] and it was shown that the absence of MsrA modifies Aβ solubility properties and causes mitochondrial dysfunction in a mouse model of Alzheimer’s disease [131,132].