This phenomenon has been observed in vitro or in vivo both in solid and in hematological disease models: BCR-ABL+ Chronic Myeloid Leukemia (CML) [7], NPM-ALK+ Anaplastic Large Cell Lymphoma (ALCL) [8,9], Gastric Cancer [10], Melanoma [11,12], Lung Cancer [13]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.