In our work for the first time we highlight the mechanisms leading to cell death upon drug withdrawal in two hematological cell lines drug resistant/drug addicted: one, LAMA-R, from a CML BCR-ABL+ imatinib resistant model, the second, SUP-M2-LR, from an ALCL NPM-ALK+ lorlatinib resistant model. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.