This phenomenon has been observed in vitro or in vivo both in solid and in hematological disease models: BCR-ABL+ Chronic Myeloid Leukemia (CML) [7], NPM-ALK+ Anaplastic Large Cell Lymphoma (ALCL) [8,9], Gastric Cancer [10], Melanoma [11,12], Lung Cancer [13]. The gene discussed is ABL1; the disease is anaplastic large cell lymphoma.