In the multivariate analysis, T stage and CSMD1 inactivation were independent prognostic factors in HNSCC [HR (95% CI), 1.97 (1.26–3.10); p = 0.003 and HR (95% CI), 1.42 (1.07–1.87); p = 0.012] (Table 2). Here, CSMD1 is linked to head and neck squamous cell carcinoma.