Studies demonstrated that irradiated low-density lipoprotein receptor (LDLR) knockout mice followed by TG2−/− bone marrow transplantation (BMT) displayed larger and deeper atherosclerotic aortic valve lesions compared with TG2+/+ BMT mice, indicating that leukocyte-derived TG2 limited the progression of atherosclerosis [105]. This evidence concerns the gene TGM2 and atherosclerosis.