Based on a recent report that ITG β4 is present on EVs (ITG β4+ EVs) such as exosomes secreted from metastatic breast cancer cells, and contributes to organotropic metastasis in breast cancer [21], we tested whether ARRDC3 inhibits the production of ITG β4+ EVs by preventing recycling of endosomal ITG β4. Here, ARRDC3 is linked to breast cancer.