In AD they are thought to be, for example, N-Methyl-d-aspartate (NMDA) receptor antagonists [13,14], acetylcholinesterase inhibitors [14,15], antioxidants [16], radical scavengers [17], monoamine oxidase inhibitors [15] and Aβ and tau aggregation inhibitors/dissolver [7]. The gene discussed is ACHE; the disease is Alzheimer disease.