IL6 and diabetes mellitus: The inflammatory mediators released by the immune system include activated complement product C3a, interleukin 6 (IL-6), and the acute-phase reactant secretory phospholipase A2 (sPLA2) [42,43] Consequently, this process can promote certain systemic diseases [44], including cardiovascular diseases, diabetes, metabolic syndrome [5], and organ abscesses at distant sites [38,45].