Similarly, in the TOPACIO study pembrolizumab (anti-PD1 monoclonal antibody) and niraparib were administered in metastatic TNBC patients and 28% of the 46 evaluable patients had objective response, the response rate being higher in patients with mutations in BRCA1/2 or HR genes found in the tumor tissue [95]. The gene discussed is BRCA1; the disease is neoplasm.