Recently, it has been reported that a 39 amino acid protease cleavable peptide fragment of prostatic acid phosphatase (PAP248–286, henceforth PAP f39, Figure 1a) found in human semen forms amyloid fibrils termed SEVI (semen-derived enhancer of viral infection) and plays a crucial role in enhancing HIV infection by ~105 fold [3]. Here, ACP3 is linked to viral infectious disease.