In particular, we analyzed the expression of Multimerin-2 a glycoprotein expressed by endothelial cells displaying angiostatic functions [20,41,42,43,47] and EMILIN-2, known to affect tumor growth both directly [36,37,38,39] and indirectly impinging on angiogenesis [38,40]. This evidence concerns the gene MMRN2 and neoplasm.