SS patients have higher levels of IFN-γ and INF-α and β mRNA in the peripheral blood and labial salivary glands in comparison to healthy individuals, and SS patients with lymphoma present lower levels of IFN-α and higher levels of INF-γ mRNA in labial salivary gland samples when compared with other SS and control individuals, supporting INF-α/γ as a predictor of lymphoma in SS [156]. This evidence concerns the gene IFNA1 and lymphoma.