The overexpression of IFN-γ, induction of pro-inflammatory genes, such as TNF-α, interleukins, and B-cell activating factor (BAFF), the promotion of B cell activation and rise in autoantibodies in the blood are involved in the physiopathology of SS [99,156,224,225,226,227,228]. Here, IFNG is linked to synovial sarcoma.