The use of a BCL-2 family inhibitor (GX15-070 or knockdown of BCL-2, BCL-XL, and MCL-1) in pancreatic cancer cells treated with SAHA or sodium valproate and sorafenib therefore induced autophagy and intrinsic apoptosis in another study accordingly, thereby helping to overcome a blockade of extrinsic apoptosis [299]. This evidence concerns the gene BCL2 and familial pancreatic carcinoma.