HDAC6 and leukemia: By LAQ824-induced inhibition of HDAC6 and consequent acetylation of its substrate HSP90, disruption of the chaperone function related to pro-growth and pro-survival oncoproteins (e.g., BCR-ABL, mutant FLT-3, c-RAF, AKT, c-KIT, Her-2, BRAF) was documented resulting in their inappropriate degradation in human leukemia cells [46].