In this regard, also selective inhibition of HDAC6 led to inappropriate degradation of unfolded, and misfolded ubiquitinated proteins that are degraded not only by proteasomes but also by HDAC6-dependent aggresomes [148]; using a combination of bortezomib and tubacin, caspase-dependent apoptosis caused by the accumulation of ubiquitylated proteins in multiple myeloma cells was induced. The gene discussed is HDAC6; the disease is AL amyloidosis.