Similarly, we showed that upon VDAC1 depletion in tumours derived from the A549 lung cancer cell line, representing non-mature AT2 cells, the residual tumour showed increased expression of the pulmonary-associated surfactant protein C, SP-C, although SP-A1 and SP-B levels were decreased (Figure 5D,E). Here, VDAC1 is linked to lung carcinoma.