Here, we showed that VDAC1 silencing in A549 cell-derived tumours resulted in reduced expression of lung-specific CSC markers [84,86], such as ALDH1, KLF4, SOX2, CD133, CD44, CD144, EPCAM, Oct3/4 and Nanog (Figure 4, Figure S1B). This evidence concerns the gene CDH5 and neoplasm.