In the case of MDA-MB-231-derived tumours treated with si-hVDAC1, the expression of ALD1HA1, KLF4, SOX2, CD133 and EPCAM were highly reduced, again as analysed by IHC, immunoblotting or q-RT-PCR (Figure 4I–L, Figure S1B). The gene discussed is KLF4; the disease is neoplasm.