For a better understanding of the molecular mechanism underlying cell signalling and gene expression alteration by si-hVDAC1 tumour treatment, we assessed the expression levels of the canonical major TFs p53, HIF-1α (hypoxia-inducible factor 1 alpha) and c-Myc, which regulate metabolism, cell growth, proliferation and differentiation [40]. The gene discussed is HIF1A; the disease is neoplasm.