This finding is in accordance with Liu’s observation [52], which indicates that inhibition of AKT is the mechanism underlying the pro-apoptotic and anti-invasive process promoted by Ole in glioma cells and with Yan’s indication [53] about the induction of apoptosis by Ole through the PI3K/AKT pathway in HepG2 human hepatoma cell line. The gene discussed is AKT1; the disease is glioma.