Thus, there are clinical studies carried out in HIV-1 seropositive subjects [24,25], with alterations in lipid metabolism [26], chronic hepatitis C virus infection [27], allergic rhinitis [28], heavy metal poisoning [29], and hypertension; but the effect of the administration of SM on sVCAM-1, sICAM-1, sE-selectin and endothelin-1 or on the indicators of oxidative stress in hypertensive patients under pharmacological control has not been evaluated. Here, EDN1 is linked to hypertensive disorder.