Given the fact that EGPA is a heterogeneous entity with potentially overlapping diseases carrying different biomarker profiles, patients could benefit from different treatment options like RTX for ANCA-positive EGPA, omalizumab or mepolizumab for ANCA-negative EGPA and imatinib for EGPA patients with mutations in TK fusion genes [91]. Here, TKT is linked to eosinophilic granulomatosis with polyangiitis.