Low expression of miR-542-3p and miR-142 is frequently found in HCC; these two miRNAs directly regulate the TGFB1 transcript by binding to the 3’-UTR [21,22] and, therefore, negatively regulate the TGF-β/Smad signaling pathway, implicating them in EMT and metastasis in HCC. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.