EZH2 and neoplasm: Regarding the epigenetic regulation of tumor suppressor genes, the upregulation of chromodomain helicase DNA binding protein 5 (CHD5), which acts as a tumor suppressor in several types of cancer [94], by shEZH2, led to a reduction in cell migration and invasion, and a negative correlation between EZH2 and CHD5 was observed in HCC patients [79].