MicroRNA-145 suppresses cell proliferation, invasion and migration in PC cells by targeting NEDD9 [16] and baicalein, a flavone ingredient of Scutellaria baicalensis Georgi inhibits PC cell proliferation and invasion via suppression of NEDD9 expression and its downstream Akt and extracellular regulated kinase (ERK) signaling pathways [17]. Here, AKT1 is linked to pachyonychia congenita.