It should be noted that for most of the myopathies studied (regardless of whether they have high or low Ca2+-sensitivity), an increase in the number of myosin heads in AM and/or AM^•ADP states was found at relaxation (Table 1), and this is one of the primary causes for disorganization of the contractile apparatus at congenital myopathies. This evidence concerns the gene MYH14 and myopathy.