Mechanisms for its cytotoxic activity against colon cancer cells include induction of apoptosis via activation of p53 and inhibition of NFκB [166,167], cell cycle arrest as a result of downregulation of cell cycle genes [168,169,170], and suppression of inflammation via downregulation of Cox2, which is commonly upregulated in colon cancer [171]. This evidence concerns the gene PTGS2 and malignant colon neoplasm.