NLRP6 and colitis: Interestingly, these changes were not observed in apigenin-treated mice deficient in the innate immune receptor NLRP6, and consistently, apigenin-treated NLRP6-deficient mice were more susceptible to DSS-induced colitis compared to apigenin-treated wildtype mice, strongly suggesting a role for NLRP6 in mediating the protective effect of apigenin as well.