NLRP6 is a member of the Nod-like receptor (NLR) family of innate immune receptors that are capable of sensing microbes and tissue damage and has been shown to be important for regulating the composition of the gut microbiota and for protecting against the development of colitis as well as inflammation-associated tumorigenesis [28,161,162,163,164]. Here, NLRP6 is linked to colitis.