Our present study is the first to investigate the combinatorial effects of ClF (used at IC50 concentration) with polyphenols, EGCG, or genistein used at the range of physiological concentrations, on breast cancer cell growth, apoptosis, and epigenetic regulation of transcriptional activity of DNA methylation-silenced tumor suppressor genes, such as RARB and PTEN. The gene discussed is RARB; the disease is breast cancer.