RARB and breast cancer: Therefore, in the present study, we investigated the effects of ClF in combination with well-known and widely studied polyphenols: Epigallocatechin gallate (EGCG, tea catechin) or genistein (soy phytoestrogen), potent inhibitors of DNA methyltransferases (DNMTs) and modulators of histone modifications [38], on RARB methylation and expression in well-defined in vitro model of human breast cancer cell lines with different invasive potential.