Upon 4 days of exposure, the combinations of ClF with EGCG or genistein caused synergistic or additive inhibition of cell growth and greater induction of apoptosis, followed by significant RARB hypomethylation with concomitant multiple increase in RARB, PTEN, and CDKN1A transcript levels, mostly in mildly malignant MCF7 breast cancer cells. This evidence concerns the gene CDKN1A and breast cancer.