PTEN and breast cancer: We showed previously that ClF used in combination with sulforaphane (SFN, an isothiocyanate from broccoli, brussels sprouts, and cabbage), demonstrated potent growth inhibitory activity in human breast cancer cells and led to robust hypomethylation and upregulation of RARB (retinoic acid receptor beta) and PTEN (phosphatase and tensin homologue) tumor suppressor genes, especially in mildly malignant breast cancer cells [4].