On the contrary, mice deficient for miR-122 rapidly developed NASH due to heightened lipogenesis, impaired lipid secretion, up-regulation of Interleukin 6 (IL-6), Tumor necrosis factor-alpha (TNF-α), C-C Motif Chemokine Ligand 2 (CCL2) and the recruitment of immune cells. The gene discussed is IL6; the disease is metabolic dysfunction-associated steatohepatitis.