PNPLA3 and metabolic dysfunction-associated steatohepatitis: Moreover, NAFLD has a strong genetic component, and variants in proteins regulating hepatocellular lipid handling, including Patatin-like Phospholipase Domain-containing 3 (PNPLA3), Transmembrane 6 Superfamily Member 2 (TM6SF2), Membrane Bound O-acyltransferase Domain-containing 7 (MBOAT7), predispose to the development and progression to NASH and fibrosis [7].