Silencing of miR-34a restored the expression of SIRT1 and Peroxisome proliferator-activated receptor α (PPARα), resulting in activation of PPARα downstream genes, such as AMPK and Hydroxymethylglutaryl-CoA Reductase (HMGCR), thus ameliorating steatosis [74]. The gene discussed is PPARA; the disease is steatosis.