Finally, we demonstrated that miR-19a is involved in malignant phenotype and aggressiveness as shown by the consistent increase S100A4, a main component of S100 family proteins, strictly associated to the malignant phenotype and metastatic behavior of various tumors [74,75,76] and decrease of CDH1, an E-cadherin, which down expression is found in several types of cancer and relates with infiltrative and metastatic behavior [77,78,79,80]. The gene discussed is S100A4; the disease is cancer.