When these two EMT triggers were considered together, the risk of invasion did not significantly differ between the subtypes of DCIS with single positive expression of either SPARC or Snail1 (SPARC−/Snail1+ vs. SPARC+/Snail1−: 6.25% vs. 14.29%, p = 0.306). Here, SPARC is linked to ductal breast carcinoma in situ.