SPARC and ductal breast carcinoma in situ: This significant difference persisted when the subtypes of single-positive DCIS were compared to double-positive DCIS separately: SPARC−/Snail1+ versus SPARC+/Snail1+ (6.25% vs. 43.08%, p < 0.0001) and SPARC+/Snail1− versus SPARC+/Snail1+ (14.3% vs. 43.08%, p = 0.044), respectively.