PIK3CA is the second most mutated gene, with overall frequencies of 25% of tumours according to the Catalog of Somatic Mutations In Cancer (COSMIC, v86 [101]) as well as of 51% and 53% in TCGA-UCEC (release 13) and the TCGA endometrial cancer genomic data, respectively ([88,95] Figure 4A,B and Figure A1). The gene discussed is PIK3CA; the disease is endometrial cancer.