RUNX1 and melanoma: It has been shown that miR17–92 cluster (miR20a2, miR92a1, miR17 and miR18a), miR126, miR182, miR210, and miR214 are upregulated and their respective target genes (Runt-related transcription factor 1 (RUNX1); Hypoxia-inducible factor 1A (HIF1A); TGF-beta type 1 serine/threonine kinase receptor (TGFBR2); Thrombospodin 1 (THBS1); and Janus kinase 2 (JAK2) are downregulated in both medaka and human melanoma model [126].