In a recent study, transgenic zebrafish harboring tissue-specific oncogenic alleles of human BRAF and NRAS downstream to a melanocyte-specific (mitf) promoter were used to manipulate zebrafish melanomas to determine the spectrum of mutations in the absence of UV light and to interrogate the role of BRAF, NRAS and p53 in melanoma in transgenic zebrafish [22]. The gene discussed is BRAF; the disease is melanoma.