RAC1 and melanoma: Signaling cascades, such as the RAS/RAF/ERK1/2 pathway, the PI3K/AKT pathway, Ras-related C3 botulinum toxin substrate 1 (RAC1) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB)-associated pathway are involved in melanoma initiation and progression in vivo [88].