TGFB1 and Autoimmunity: B-TβRII-KO mice with a selective deficiency in TGFβ signaling in B cells show increased levels of serum Igs and produce anti-ds DNA antibodies [76], although these autoimmune manifestations are less severe than those observed in mice TGFβ1-KO or T-TβRII-KO (Tgfbr2f/f Cd4-Cre) mice which develop severe multi-organ inflammation and autoimmunity [4,5,28].