These new classes of anti-myeloma drugs include immunomodulators (thalidomide, lenalidomide, and pomalidomide), proteasome inhibitors (bortezomib, carfilzomib, and ixazomib), and histone deacetylase (HDAC) blockers (panobinostat) [2]. This evidence concerns the gene HDAC9 and plasma cell myeloma.