The immune deficiency (IMD) pathway on the other hand is preferentially activated by sensing diaminopimelic acid-type peptidoglycan (DAP-PGN) [63], which is a component of the cell wall of Gram-negative bacteria, and regulates the expression of antibacterial peptides such as Diptericin following nuclear translocation of another NF-kB transcription factor: Relish [56]. Here, NFKB1 is linked to Immunodeficiency.