Due to possible result of natural selection, frequencies of UGT1A1 gene variants vary among people with different populations.[5,6] A(TA)7TAA (c.-40_-39dupTA or, c.-40_-39insTA) polymorphism in the promoter region was related to GS among Caucasians,[7,8] while G71R polymorphism in the coding region was related to GS among East Asians.[9,10] With regard to neonatal hyperbilirubinemia, CNS-I, CNS-II phenotypes, frequencies of genetic mutations were also different between Caucasians and East Asians.[7–18]. The gene discussed is UGT1A1; the disease is Hyperbilirubinemia.