AFP and hypersplenism: Previous studies have shown that tumor size, Edmondson–Steiner histological grade, number of nodules, and alpha-fetoprotein (AFP) level are associated with PVTT.[20] While low albumin levels, tumor size >5 cm, metastases, ascites, AFP >1000 ng/mL, and hypersplenism have been found to be independent predictive factors of MVI,[21–23] these indicators cannot properly predict the risk of MVI.